Dynapar QPS is a quick penetrating solution of Diclofenac, based on the QPS Novel Drug Delivery Platform. With QPS formulation, absorption of Diclofenac starts promptly at the site of topical application. This transports high levels of diclofenac in the tissue surrounding the site of application.
The paracellular lipid mortar component of the structure is the primary route of penetration of all topical chemicals. QPS technology utilises a unique base in which the drug is solubilised. The base is absorbed into the skin, thereby carring the solubilised drug through the barrier of the stratum corneum. QPS base being non-aqueous, passes through the paracellular lipid matrix, thereby providing enhanced penetration. The excipients and its proportions in QPS base were optimised after a series of pharmacokinetic studies. The optimised formulation provides adequate transdermal penetration. When applied on the skin, the base is absorbed into the skin, thereby carring the drug through the barrier of the stratum corneum.
Hence, paracellular transport across the stratum corneum is the QPS mechanism of penetration, which provides enhanced penetration through the skin. The higher penetration of QPS through the skin is validated and established by way of several scientific studies.