Product Information

The Research and Development department of Troikaa Pharmaceuticals Ltd. has worked relentlessly to overcome the problem of poor penetration and hence, has successfully developed a novel technology – the QPS Technology.

The acronym QPS stands for Quick Penetrating Solution, it is a novel patented drug delivery platform that provides quick and comprehensive penetration of the drug through the skin.

Two variants of diclofenac QPS have been developed, namely, Dynapar QPS and Dynapar QPS Plus. Both Dynapar QPS and Dynapar QPS Plus are based on the same path breaking drug delivery platform. They provide freedom to select an appropriate formulation depending upon the physician’s clinical judgment as well as the patient’s preference to counter irritants.

Medical uses:
Dynapar QPS contains a non-steroidal anti-inflammatory (NSAID) drug used to treat mild to moderate pain and inflammation, particularly musculoskeletal pain. It is the world’s first transdermal preparation of diclofenac solution, providing superior pain relief after topical application by enhancing the penetration of diclofenac through the skin. The preparation is backed by proof of concept pharmacokinetic studies, as well as clinical trials. Since Dynapar QPS provides prompt pain relief upon being applied to any inflamed area (knee, back, elbow, neck, ankle, etc.), it minimises or eliminates the patient's requirement of oral pain killers. Dynapar QPS, therefore, brings a paradigm shift in the management of musculoskeletal pain.

How it works:
Dynapar QPS is a quick penetrating solution of diclofenac, based on the QPS Novel Drug Delivery Platform. The QPS formulation enables quick absorption of diclofenac at the site of topical application, leading to high levels of the drug in the tissue surrounding the site of application. Better transdermal penetration is achieved through enhanced paracellular movement of the QPS base, within which, diclofenac is solubilised. The mechanism of penetration of QPS is paracellular transport across the stratum corneum which provides enhanced penetration into the skin. QPS technology utilises a unique base in which the drug is solubilised. The base is absorbed into the skin, carrying the solubilised drug through the barrier of the stratum corneum. Being non-aqueous, the QPS base passes through the paracellular lipid matrix, thereby, providing enhanced penetration. The excipient, and its proportion in the QPS base, has been optimised after a series of pharmacokinetic studies. The optimised formulation provides adequate transdermal penetration.

Pharmacokinetics:
When Dynapar QPS is applied locally, the active substance (diclofenac) is well  penetrated and absorbed through the skin. The time to reach maximum concentration of diclofenac after local application is approximately 5 hours. Diclofenac is more than 99% bound to human serum proteins, primarily to albumin.

Dosage and administration:
Dynapar QPS delivers 4 mg of diclofenac in each actuation (pump stroke). Dynapar QPS Plus delivers 2 mg of diclofenac in each actuation. Each pump stroke delivers 0.1ml of the solution. The recommended dose of Dynapar QPS and Dynapar QPS Plus is 4 sprays 4 times daily.

Safety Information
Mechanism of Action

Dynapar QPS is a quick penetrating solution of Diclofenac, based on the QPS Novel Drug Delivery Platform.

Unique Spray Pump

Dynapar QPS is provided in a metered dose spray which delivers 4 mg of diclofenac on each pump stroke.

How To Apply

Before using Dynapar QPS or Dynapar QPS Plus for the first time, you may need to prime the pump by spraying it into the air 2-3 times.

Contact Us

Troikaa Pharmaceuticals Ltd.,
Commerce House - 1,
Satya Marg, Bodakdev,
Ahmedabad-380 054.
Gujarat, India.